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General chemical structure of a paraben
where R = an alkyl group
Parabens are a class of chemicals widely used as preservatives by cosmetic and pharmaceutical industries. Parabens are effective preservatives in many types of formulas. These compounds, and their salts, are used primarily for their bactericidal and fungicidal properties. They can be found in shampoos, commercial moisturizers, shaving gels, personal lubricants, topical/parenteral pharmaceuticals, spray tanning solution, makeup, and toothpaste. They are also used as food additives.
Their efficacy as preservatives, in combination with their low cost, the long history of their use, and the inefficacy of some natural alternatives like grapefruit seed extract (GSE), probably explains why parabens are so commonplace. They are becoming increasingly controversial, however, because they have been found in breast cancer tumors (an average of 20 nanograms/g of tissue). Parabens have also displayed the ability to slightly mimic estrogen (a hormone known to play a role in the development of breast cancer). No effective direct links between parabens and cancer have been established, however. Another concern is that the estrogen-mimic aspect of parabens may be a factor in the increasing prevalence of early puberty in girls.
Parabens are esters of para-hydroxybenzoic acid, from which the name is derived. Common parabens include methylparaben (E number E218), ethylparaben (E214), propylparaben (E216), butylparaben and heptylparaben (E209). Less common parabens include isobutylparaben, isopropylparaben, benzylparaben and their sodium salts. The general chemical structure of a paraben is shown at the top right of this page, where R symbolizes an alkyl group such as methyl, ethyl, propyl or butyl.
Some parabens are found naturally in plant sources. For example, methylparaben is found in blueberries, where it acts as an antimicrobial agent.
All commercially used parabens are synthetically produced, although some are identical to those found in nature. They are produced by the esterification of para-hydroxybenzoic acid with the appropriate alcohol, such as methanol, ethanol, or n-propanol. para-Hydroxybenzoic acid is in turn produced industrially from a modification of the Kolbe-Schmitt reaction, using potassium phenoxide and carbon dioxide.
Studies on the acute, subchronic, and chronic effects in rodents indicate that parabens are practically non-toxic. Parabens are rapidly absorbed, metabolized, and excreted. The major metabolites of parabens are p-hydroxybenzoic acid (pHBA), p-hydroxyhippuric acid (M1), p-hydroxybenzoyl glucuronide (M3), and p-carboxyphenylsulfate (M4).
In individuals with normal skin, parabens are, for the most part, non-irritating and non-sensitizing. Parabens can, however, cause skin irritation and contact dermatitis and rosacea in individuals with paraben allergies, a small percentage of the general population.
Average levels of 20 nanograms/gram of parabens have been detected in a small sample of 20 breast tumors. These findings, along with the demonstrated ability of some parabens to partially mimic estrogen, a hormone known to play a role in the development of breast cancers, have led some scientists to conclude that the presence of parabens may be associated with the occurrence of breast cancer, and to call for investigation into whether or not a causal link exists. The lead researcher of the UK study, molecular biologist Philippa Darbre, reported that the ester-bearing form of the parabens found in the tumors indicate that they came from something applied to the skin, such as an underarm deodorant, cream or body spray, and stated that the results helped to explain why up to 60% of all breast tumors are found in just one-fifth of the breast - the upper-outer quadrant, nearest the underarm. "From this research it is not possible to say whether parabens actually caused these tumors, but they may certainly be associated with the overall rise in breast cancer cases. Given that breast cancer is a large killer of women and a very high percentage of young women use underarm deodorants, I think we should be carrying out properly funded, further investigations into parabens and where they are found in the body," says Philip Harvey, an editor of the Journal of Applied Toxicology, which published the research. A 2004 study at Northwestern University found that an earlier age of breast cancer diagnosis related to more frequent use of antiperspirants/deodorants and underarm shaving. "I personally feel there is a very strong correlation between the underarm hygiene habits and breast cancer," said immunologist Dr. Kris McGrath, the author of the study.
This research has fueled a popular belief that the parabens in underarm deodorants and other cosmetics can migrate into breast tissue and contribute to the development of tumors.
No direct evidence of a causal link between parabens and cancer, however, has been shown. A 2005 review of the data available at that time concluded "it is biologically implausible that parabens could increase the risk of any estrogen-mediated endpoint, including effects on the male reproductive tract or breast cancer" and that "worst-case daily exposure to parabens would present substantially less risk relative to exposure to naturally occurring endocrine active chemicals in the diet such as the phytoestrogen daidzein." The American Cancer Society also concluded that there was insufficient scientific evidence to support a claim that use of cosmetics such as antiperspirants increase an individual's risk of developing breast cancer, but went on to state that "larger studies are needed to find out what effect, if any, parabens might have on breast cancer risk.
Animal experiments have shown that parabens have weak estrogenic activity, acting as xenoestrogens. In an in vivo study, the effect of butylparaben was determined to be approximately 100,000 times weaker than that of estradiol, and was only observed at a dose level approximately 25,000 times higher than the level typically used to preserve products. The study also found that the in vivo estrogenic activity of parabens is reduced by about three orders of magnitude compared to in vitro activity.
The estrogenic activity of parabens increases with the length of the alkyl group. It is believed that propylparaben is estrogenic to a certain degree as well, though this is expected to be less than butylparaben by virtue of its less lipophilic nature. Since it can be concluded that the estrogenic activity of butylparaben is negligible under normal use, the same should be concluded for shorter analogs.
Some estrogens are known to drive the growth of tumors; however the estrogenic activity and mutagenic activity of estrogens are not the same, with the latter dependent on free radical chemistry and not estrogen receptor activity. Nonetheless, this study has elicited some concern about the use of butylparaben, and to a lesser extent other parabens as well, in cosmetics and antiperspirants. A 2005 safety assessment of parabens concluded that cosmetics containing parabens do not, on the basis of currently available evidence, pose a health risk; because of the low doses involved and the low probability that parabens will penetrate into the tissue, remain intact, and accumulate there.
Studies indicate that methylparaben applied on the skin may react with UVB leading to increased skin aging and DNA damage.
The European Scientific Committee on Consumer Products (SCCP) stated in 2006 that the available data on parabens do not enable a decisive response to the question of whether propyl, butyl and isobutyl paraben can be safely used in cosmetic products at individual concentrations up to 0.4%, which is the allowed limit in the EU.
The above-mentioned studies have resulted in scientific debate that in turn led to popular controversy largely propagated by mass e-mail. Darbre's paper led to further discussion over possible carcinogenicity and estrogenic effects being expressed over the continued use of parabens as preservatives.
The mainstream cosmetic industry believes that parabens, like most cosmetic ingredients, are safe based on their long term use and safety record and recent scientific studies. Public interest organizations which raise awareness about cosmetic ingredients believe that further research is necessary to determine the safety of parabens (see also precautionary principle). The concerns about endocrine disruptors have led consumers and companies to search for paraben free alternatives. Grapefruit seed extract that is promoted as a natural preservative was identified as containing artificial preservatives such as methylparaben.
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^ The American Cancer Society Antiperspirants and Breast Cancer Risk
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