Absolutely, without a doubt. We have a history of gender-based authoritarianism, which includes behavioral expectations of both binary genders, and failure to uphold those normative values and behaviors leads to socioeconomic and political consequences, and often quite severe ones. Protected classes MUST include those whose gender/sex and/or gender/sex performance leads to widespread discrimination and social exclusion. These categories should NOT be based on numbers such as percentage of the population (as Christians can be protected as they are a religious group, despite the fact that most claims are not forms of actual discrimination), but based on power differentials within society. It doesn't matter whether or not you agree or disagree with a person's identity; they still deserve all the rights and privileges afforded to them by the Constitution.