To be successful entrepreneurs need both technical and marketing savvy. Technical success includes securing patent protection and/or establishing trade secrets. Taking federal money comes with long strings confounding ownership in certain areas. The last NSF grant that I was awarded came with the proviso that I couldn’t keep any technology that I developed. I had to share it with the world for free. I was totally discouraged. I say the federal government, through NSF should stay out of small business startups, focusing instead on University-lead research.