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Support research to develop less- toxic therapies that will not leave kids with lifelong side-effects.

Despite very aggressive therapies that approach the limits of tolerability for the child, the overall survival rate for childhood cancer has remained unchanged since 1998. One in four children who are diagnosed with cancer in the U.S. will die within five years of their diagnosis, and 30% of those that do survive have severe side effects, including cognitive deficits, kidney failure, heart failure, and secondary cancers caused from the traditional toxic treatments. Because of the high level of toxicity associated with many current treatments and the plateau in survivorship rates, future success is dependent upon the development of new therapeutic approaches.